Nitrates in the management of acute coronary syndrome. isosorbide mononitrate, along with See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. List of Antianginal agents (antianginal drugs) - Drugs.com For instance, many herbal supplements that are used often interact with the blood thinner warfarin (Jantoven). The https:// ensures that you are connecting to the Which drugs or supplements interact with isosorbide mononitrate? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Isosorbide mononitrate helps to prevent angina chest pain from developing. Enter other medications to view a detailed report. Highly clinically significant. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. and transmitted securely. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. Follow directions about how much medicine to take. information is beneficial, we may combine your email and website usage information with 1998 Oct;61(10):577-83. health information, we will treat all of that information as protected health These side effects may go away during treatment as your body adjusts to the medicine. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Prescribed for Angina, Anal Fissure and you should know that you may experience headaches every day during your treatment with isosorbide. You can start a phase IV clinical trial to monitor Isosorbide mononitrate safety and effectiveness. Isosorbide mononitrate: isosorbide mononitrate. This branded product is no longer on the market. This medicine is available only with your doctor's prescription. Alternative drugs to the conditions Isosorbide mononitrate treats: Angina High blood pressure Stable angina Chest pain Heart disease Heart attack Angina unstable Heart disease congenital Coronary heart disease Heart failure Pulse Heart rate irregular Coronary artery spasm Angioplasty . National Library of Medicine Alcohol or marijuana (cannabis) can make you more dizzy. This makes it easier for your heart to pump, relieving heart-related chest pain. Higher dosages are associated with stomach irritation and Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. It works and leaves the body quickly, so it needs to be taken twice a day. You can develop a tolerance to isosorbide mononitrate (Monoket) over time, which means the dose you've been taking doesn't work as well. Isosorbide: MedlinePlus Drug Information However, you should not flush this medication down the toilet. Isosorbide mononitrate Interactions - Drugs.com Does Isosorbide Mononitrate interact with other medications? Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. Isosorbide extended-release (long-acting) tablets and extended-release capsules are used for the management of chest pain in people who have coronary artery disease. flushing - try to cut down on coffee, tea and alcohol because they can make flushing worse. Imdur vs. Isordil - RxList MeSH If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. What special dietary instructions should I follow? If you forget to take a dose, take it as soon as you remember. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). If any of these effects persist or worsen, tell your doctor or pharmacist promptly. 88 ratings on Drugs.com. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Your doctor will tell you which is the right dose for you, and this will also be printed on the label of the pack to remind you about what the doctor said to you. Isosorbide Mononitrate - Uses, Side Effects, and More - WebMD Some people feel dizzy or fall when changing positions, such as going from sitting to standing. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. Valerian: A safe and effective herbal sleep aid? Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. Mehta D. Botanical medicines. tell your doctor and pharmacist if you are allergic to isosorbide; nitroglycerin tablets, patches, or ointment; any other medications, or any of the ingredients in isosorbide tablets, extended-release tablets, or extended-release capsules. Watch for any symptoms that you may be having a drug interaction, such as: Mayo Clinic does not endorse companies or products. Accessed Sept. 7, 2022. Avoid combinations; the risk of the interaction outweighs the benefit. It relaxes blood vessels in your body (causing them to widen) and this reduces the strain on your heart, making it easier for your heart to pump blood around your body. Herbal supplements can strongly affect the body. Be sure to mention any of the following: aspirin; beta blockers such as atenolol (Tenormin, Tenoretic), carteolol , labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, in Dutoprol, in Lopressor HCT), nadolol (Corgard, in Corzide), propranolol (Hemangeol, Inderal, Innopran), sotalol (Betapace, Sorine, Sotylize), and timolol; calcium channel blockers such as amlodipine (Norvasc, in Amturnide, in Tekamlo), diltiazem (Cardizem, Cartia, Dilt-CD, others), felodipine (Plendil), isradipine, nifedipine (Adalat CC, Afeditab, Procardia), and verapamil (Calan, Covera, Verelan); ergot-type medications such as bromocriptine (Cycloset, Parlodel), cabergoline, dihydroergotamine (D.H.E. Eur Heart J. This risk may be even higher for certain groups. Meinertz T, Lehmacher W; Trapidil/ISDN Study Group. Isosorbide mononitrate (Monoket) is good for a specific type of chest pain (called angina), but it can cause headaches or dizziness after you take it. Headaches can be a sign that the medicine is working, and they might lessen with continued use of the medication. Ginkgo. Dated October 2016. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Please see a good cardiologist, get admitted, get checked thoroughly. To provide you with the most relevant and helpful information, and understand which It does not work fast enough to relieve the pain of an angina attack that has already started. Even if the medication is working, you may experience some unwanted side effects. Natural Medicines. Pregnancy:Data on the use of isosorbide mononitrate during pregnancy are insufficient to be able to assess the possible harmful effect. US residents can call their local poison control center at 1-800-222-1222. Pricing based on most commonly-filled versions: 180 tablets of isosorbide mononitrate 10mg. The Swedish Multicentre Group. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Isosorbide Mononitrate (Oral Route) - Mayo Clinic Isosorbide-5-mononitrate ISMN usually begins acting within 30 minutes and its effects last six to eight hours. It also may keep some medicines from working as well as they should, such as: If your health care provider tells you it's OK to use an herbal supplement along with medicine, be careful. Accessed Sept. 7, 2022. FOIA Your body can get used to isosorbide mononitrate (Monoket), and the same amount of medication might no longer work as well as it used to. Isosorbide mononitrate belongs to the group of medicines called nitrates. All rights reserved. What You Need to Know, Angina (a specific type of chest pain) caused by heart disease. 2010; doi:10.1016/j.jacc.2009.07.074. Many common herbal supplements interact with common heart medicines. What should I know about storage and disposal of this medication? The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Some of these medicine interactions can be risky. Please note that only the generic name of each medication is listed below. Now, youll enjoy a streamlined experience created specifically for healthcare providers. It is important to take the drug at the same times each day. The extended-release tablet usually is taken once daily in the morning. ** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. What side effects can this medication cause? Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets; Merus Labs Luxco S.a.R.L, The electronic Medicines Compendium. Daily headaches are a common side effect. Commonly reported side effects include: See also: isosorbide mononitrate side effects in more detail. It is unknown if this medication passes into breast milk. Some of these medicine interactions can be risky. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Danshen. It is components of vit. Stopping isosorbide mononitrate (Monoket) suddenly can cause you to have a worsening of your chest pain. This content does not have an English version. Elsevier; 2021. https://www.clinicalkey.com. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Alternative cancer treatments: 11 options to consider. Don't drink alcohol while taking isosorbide mononitrate (Monoket). Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. Aspirin has an average rating of Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). Almost 70% of older adults use them. Contraindications: Isosorbide mononitrate should not be used in cases of acute myocardial infarction with low filling pressure, acute circulatory failure (shock, vascular collapse), or hypertrophic obstructive cardiomyopathy (HOCM), constrictive pericarditis, low cardiac filling pressures, aortic/mitral valve stenosis and diseases associated with a raised intra-cranial pressure e.g following a head trauma and including cerebral haemorrhage. There are a number of medications that your doctor can prescribe in place of isosorbide mononitrate (Monoket). This is called a medicine interaction. Your doctor will prescribe you a short-acting nitrate for you to take if this happens. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Making any changes without doctor's advice can be dangerous. Sildenafil ( Viagra ), tadalafil ( Cialis ), avanafil ( Stendra ),and vardenafil ( Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. You may report side effects to the FDA at 1-800-FDA-1088. May also be prescribed off label for Esophageal Spasm. sharing sensitive information, make sure youre on a federal 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Isosorbide dinitrate (Isordil): Basics, Side Effects & Reviews - GoodRx Available for Android and iOS devices. If you have ever had an allergic reaction to a medicine. The list below does not include all possible drug interactions with isosorbide mononitrate (Monoket). Can cause dizziness, especially when you change positions, Interacts with erectile dysfunction medications. We don't support your browser. Portions of this document last updated: Feb. 01, 2023. This product may contain inactive ingredients, which can cause allergic reactions or other problems. A single copy of these materials may be reprinted for noncommercial personal use only. These relax smooth muscle within the blood vessels, widening them and making it easier for blood and oxygen to reach the heart Calcium antagonists (eg, diltiazem, nifedipine, nimodipine, verapamil). Isosorbide mononitrate is used to prevent chest pain in patients with a certain heart condition (coronary artery disease).This medication belongs to a class of drugs known as nitrates. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or to 30 mg 5-ISMN od for one week followed by 60 mg 5-ISMN od for one week. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Isosorbide mononitrate - UpToDate Isosorbide Mononitrate - Medicine.com Results: It will not treat an angina attack that has already begun. https://www.uptodate.com/contents/search. Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). You can consult me online for homeopathic treatment. 2005 - 2023 WebMD LLC. Let your provider know if you are using any medications for erectile dysfunction before you start taking isosorbide mononitrate (Monoket). Murray MT. Take them to your local pharmacy which will dispose of them for you. 41% of reviewers reported a positive effect, while 50% reported a negative effect. If you notice any other effects, check with your healthcare professional. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat. Liperoti R, et al. Swallow the tablet/capsule whole - do not chew or crush it before you swallow. https://naturalmedicines.therapeuticresearch.com. (2) One in 3 patients never experienced headache from the given dosages. . This is called a medicine interaction. In Canada - Call your doctor for medical advice about side effects. Important information about all medicines, Notes on Isosorbide mononitrate dose and side-effects info, https://patient.info/medicine/isosorbide-mononitrate-elantan-imdur-isotard-monomax-tardisc-xismox, Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets, Carmil XL; Chemydur XL; Elantan LA; Imdur; Isib XL; Ismo; Isodur XL; Isotard XL; Modisal XL; Monomax SR; Monomil XL; Nyzamac SR; Relosorb XL; Tardisc XL; Trangina XL; Xismox XL; Zemon XL, Tablets, modified-release (longer-acting) tablets, and modified-release (longer-acting) capsules, Ask your doctor or pharmacist to recommend a suitable painkiller. Patient does not provide medical advice, diagnosis or treatment. The two dosage regimens were equally efficient for the relief of angina pectoris without development of tolerance. Profen and Metoclopramide drug interaction, Metoclopramide and Nitrostat drug interaction, Metoclopramide and Alfentanil drug interaction, Risperdal and Metoclopramide drug interaction. Classes: Nitrates, Angina Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths tablet 10mg 20mg. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction. This list covers only some interactions. Usually avoid combinations; use it only under special circumstances. Isosorbide mononitrate. This medicine is a white, round, scored, tablet imprinted with "KU 107" and "20". This drug may make you dizzy. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. This is so your doctor can check on your progress. Accessed Sept. 7, 2022. Side effects : headache, mild dizziness Please enable it to take advantage of the complete set of features! It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. Using this medicine with any of the following medicines is not recommended. If you have an eye condition called glaucoma. Bookshelf Unless there is a specific reason you need the brand, the generic medication will be a better value. Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Isosorbide tablets are also used with other medications to treat heart failure. Prices for isosorbide mononitrate (Monoket) start at just $29.86 with a GoodRx coupon. Generic alternatives may be available. Accessed Sept. 7, 2022. Natural Medicines. Take extra precautions to avoid falling during your treatment with isosorbide. Accessed Sept. 7, 2022. This medication belongs to a class of drugs known as nitrates. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. It is in the nitrate class of drugs. Isosorbide mononitrate dose 10 mg twice daily to 120 mg daily in divided doses. Properly discard this product when it is expired or no longer needed. The most common side-effect is headache. In: Current Medical Diagnosis & Treatment 2022. Talk to your doctor about the possible risks of using this medication for your condition. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Always consult your healthcare provider. Natural Medicines. Nitrates | Prescribing information | Angina | CKS | NICE Modified-release nitrate preparations: use a once-daily dose to maintain a nitrate-low period and thus minimize tolerance. This form of skin cancer is mostly caused by PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care, MBBS, Master in Healthcare Administration, Diploma in Occupational Health, What are the uses of Isosorbide Mononitrate. Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. Isosorbide mononitrate helps to prevent angina chest pain from developing. Background: Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Try to keep your regular appointments with your doctor. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Thirty percent of the patients never experienced headache from the given dosages. Dehydration in Buspar, how severe and when it was recovered? prevention of anginal chest pain associated with coronary artery disease, prevent bleeding varicose vein in the esophagus. Cleophas TJ, Niemeyer MG, van Der Wall EE. Breastfeeding:There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Information is also available online at https://www.poisonhelp.org/help. You may report side effects to the FDA at 1-800-FDA-1088. Isosorbide mononitrate (Monoket): Basics, Side Effects & Reviews - GoodRx Botanical medicine A modern perspective. Yet many herbal supplements may interact with heart disease medicines. This document does not contain all possible drug interactions. Herbal supplements are natural, so they must be safe, right? The information on this page is written and peer reviewed by qualified clinicians. other information we have about you. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. Nitroglycerin has an average rating of My cardiologist recommended I get on metropolol. Isosorbide mononitrate is used to prevent chest pain (angina) in patients with a certain heart condition (coronary artery disease). Cardizem Alternatives Compared - Drugs.com 1996 Dec;3(12):802-806. doi: 10.1097/00045391-199612000-00003. Imdur, Monoket (isosorbide mononitrate) dosing, indications - Medscape Herbal supplements and heart medicines may not mix, Your blood pressure, if you also take a drug to treat high blood pressure, Beta blockers, such as atenolol (Tenormin), nadolol (Corgard) or propranolol (Inderal LA, Innopran XL), Calcium channel blockers, such as diltiazem, nifedipine (Procardia) and verapamil (Calan SR, Verelan), Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil), Statins, such as atorvastatin (Lipitor), lovastatin (Altoprev) and rosuvastatin (Crestor), Anti-rejection medicine, also called immunosuppressant medicine, such as cyclosporine (Gengraf, Neoral, Sandimmune). My EKG showed Assess your symptoms online with our free symptom checker. Learn to reduce stress through mindful living. If you are a Mayo Clinic patient, this could Registered in England and Wales. Lifestyle changes such as dietary changes, exercise, and not smoking may help this drug work better. Store at room temperature away from light and moisture. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. Is it safe to drive while on this medicine? What happens if I stop taking isosorbide mononitrate (Monoket)? Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks ( chest pain ). Isosorbide mononitrate is very similar to isosorbide dinitrate. information and will only use or disclose that information as set forth in our notice of Evening primrose. 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (in Cafergot, in Migergot), methylergonovine (Methergine), methysergide (Sansert; no longer available in the U.S.), and pergolide (Permax; no longer available in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat. In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). Heres what you need to know about alcohol and blood pressure including how alcohol can interact with your blood pressure medications. A very serious allergic reaction to this drug is rare. Along with its needed effects, a medicine may cause some unwanted effects. It is used to treat and prevent a wide range of different conditions. Copyright, 2023. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or . Your doctor will probably tell you not to take isosorbide if you are taking one of these medications. Normal ecg doesn't rule out heart disease. Isosorbide mononitrate (Monoket) works slowly to help prevent chest pain. Take the missed dose as soon as you remember it. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. We asked 34 people what they think about isosorbide mononitrate (Monoket): Get Isosorbide mononitrate (Monoket) for as low as $29.86, 180 tablets of isosorbide mononitrate 10mg. Does isosorbide mononitrate (Monoket) lower blood pressure? It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. If you are having an operation or dental treatment, please remember to tell the person carrying out the treatment which medicines you are taking. Isosorbide mononitrate (Monoket) is available as a generic medication and may be significantly cheaper compared to the brand version. In: Current Medical Diagnosis & Treatment 2022. https://naturalmedicines.therapeuticresearch.com. include protected health information. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). View more. Cao HY, Wu HD, Song ZK, Tang ML, Yang S, Liu Y, Qin L. Pan Afr Med J. Diabetes treatment: Can cinnamon lower blood sugar? Consult your doctor before breast-feeding. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Isosorbide dinitrate (Isordil) is available as both a short-acting tablet and long-acting capsule. Some brands of isosorbide mononitrate tablets should be taken two or three times a day. https://naturalmedicines.therapeuticresearch.com. Organic Nitrate - an overview | ScienceDirect Topics View World Anti-Doping Agency classifications, Prevention of Thromboembolism in Atrial Fibrillation, Prosthetic Heart Valves - Thrombosis Prophylaxis, Prosthetic Heart Valves - Mechanical Valves - Thrombosis Prophylaxis, Revascularization Procedures - Prophylaxis. Elantan, Imdur, Isotard, Monomax, Tardisc, Xismox. Generic alternatives may be available. Do not store in the bathroom. Talk to your provider if you notice your chest pain starts to get worse. May also be prescribed off label for Esophageal Spasm. This is because the tablets/capsules are specially made to release the medicine they contain in a controlled way. Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure. Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. Take this medication by mouth as directed by your doctor, usually twice a day. Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide dinitrate, nitroglycerin); or if you have any other allergies. Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Less commonAbnormal heart soundabsence of or decrease in body movementarm, back, or jaw painblack, tarry stoolsbladder painbleeding after defecationbleeding gumsblood in the urine or stoolsblurred visionbody aches or painburning while urinatingburning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelingschest pain or discomfortchest tightness or heavinesschillscold sweatscoldsconfusionconvulsionscough or hoarsenessdecreased urinediarrheadifficult or labored breathingdifficult, burning, or painful urinationdilated neck veinsdizzinessdizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting positiondry mouthear congestionextra heartbeatsfaintingfast, slow, irregular, pounding, or racing heartbeat or pulsefever or chillsflu-like symptomsfrequent urge to urinatefrequent urinationgeneral feeling of discomfort or illnessheadacheheadache, severe and throbbingheart murmurincreased need to urinateincreased sweatingincreased thirstincreased volume of pale, dilute urineirregular breathingitching, pain, redness, or swelling on the legjoint pain, stiffness, or swellinglightheadednessloss of appetiteloss of voicelower back, side, or stomach painmuscle aches and painsmuscle crampsnasal congestionnausea or vomitingnervousnessnumbness or tingling in the hands, feet, or lipspain or discomfort in the arms, jaw, back, or neckpain, tension, and weakness upon walking that subsides during periods of restpartial or slight paralysispassing urine more oftenpinpoint red or purple spots on the skinpounding in the earsrunny noseshakiness in the legs, arms, hands, or feetshiveringsneezingsore on the legsore throatsudden decrease in the amount of urinesweatingswellingswelling of the face, fingers, feet, or lower legstightness in the chesttrembling or shaking of the hands or feettrouble sleepingtroubled breathinguncomfortable swelling around the anusunusual bleeding or bruisingunusual tiredness or weaknessvomiting of blood or material that looks like coffee groundsweaknessweight gainRareBluish-colored lips, fingernails, or palmsdark urinepale skinrapid heart rateGet emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdoseBlurred or loss of visionbulging soft spot on the head of an infantchange in consciousnesschange in the ability to see colors, especially blue or yellowcold, clammy skindisturbed color perceptiondouble visionfeeling of constant movement of self or surroundingshalos around lightsheadache, severe and throbbingloss of consciousnessnight blindnessoverbright appearance of lightsparalysissensation of spinningtunnel visionSome side effects may occur that usually do not need medical attention.